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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: Unveiling the therapeutic potential of Dl-3-n-butylphthalide in NTG-induced migraine mouse: activating the Nrf2 pathway to alleviate oxidative stress and neuroinflammation

Fig. 5

Effect of NBP on the level of oxidative stress in the SP5C. A ROS levels were significantly increased in the SP5C of the NTG + Oil group compared to the Control + Oil group and significantly decreased in the NTG + NBP group compared to the NTG + Oil group. B MDA levels were significantly higher in the SP5C of the NTG + Oil group compared to the Control + Oil group and significantly lower in the NTG + NBP group compared to the NTG + Oil group. C SOD levels were significantly decreased in the SP5C of the NTG + Oil group compared to the Control + Oil group and significantly increased in the NTG + NBP group compared to the NTG + Oil group. (n = 6–8 in each group; ***p < 0.001 and ****p < 0.0001 compared with the Control + Oil group; #p < 0.05 and ####p < 0.0001 compared with the NTG + Oil group)

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The Journal of Headache and Pain

ISSN: 1129-2377

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