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Table 1 Efficacy inputs for migraine treatments in the economic model

From: An economic evaluation of eptinezumab for the preventive treatment of migraine in the UK, with consideration for natural history and work productivity

Results over 12 weeks of treatment, with standard error (SE)

TF3+ EM,

 ≥ 50% reduction in MMDs

TF3+ CM,

 ≥ 30% reduction in MMDs

TF3+ CM,

 ≥ 50% reduction in MMDs (scenario)

Responder rate, BSC, %

9.6 (2.0)

23.2 (4.6)

8.9 (1.8a)

Responder rate, eptinezumab 100mg, %

40.0 (8.0)

63.4 (12.9)

30.4 (6.1a)

Change from baseline in MMDs, BSC responders

-5.82 (1.50)

-8.80 (1.99)

-10.45 (1.41)

Change from baseline in MMDs, eptinezumab 100 mg responders

-6.82 (0.92)

-9.93 (1.41)

-12.68 (1.40)

Change from baseline in MMDs, BSC non-responders

-1.31 (0.84)

-0.85 (1.42)

-1.94 (0.96)

Change from baseline in MMDs, eptinezumab 100 mg non-responders

-1.39 (1.18)

-1.71 (2.28)

-4.52 (1.17)

  1. Key BSC, best supportive care, CM chronic migraine, EM episodic migraine, MMDs monthly migraine days, SE standard error, TF3+ have tried three or more other preventive treatments that failed
  2. aSE = 20% of mean estimate