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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1α levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation

Fig. 4

Data are shown as whisker-box plots (whisker: full range; line: median; cross: mean). a CM + MOH patients had significantly higher HADS-A scores compared to EM patients (p = 0.002) and healthy controls (p < 0.0001) and HADS-A scores were also higher in EM patients compared to healthy controls (p < 0.0001), b CM + MOH patients had significantly higher HADS-D scores compared to EM patients (p = 0.007) and healthy controls (p < 0.0001) and HADS-D scores were also higher in EM patients compared to healthy controls (p = 0.001) (c) HIT-6 scores were significantly higher in the CM + MOH group compared to the EM group (p < 0.0001) and (d) MigSCog scores were significantly higher in the CM + MOH patients compared to EM patients (p < 0.0001). Statistical analysis was performed with one way-ANOVA followed by post-hoc Šidák’s test for multiple comparisons for HADS-A and HADS-D. Data analysis was performed with Mann-Whitney’s U test for HIT-6 scores and student t-test for MigSCog scores. * p < 0.05

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The Journal of Headache and Pain

ISSN: 1129-2377

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