Table 2 Major results of the Parts 1 and 2

Part 1: Temporal investigations

Acute stage analysis

Healthy controls (HCs)

Acute group

p

 Number of subjects

42

84

-

 Age (y)

46.0 ± 4.5

47.0 ± 12.4

0.510

 Number of females

35 (83.3%)

68 (81.0%)

0.725

 Disease onset to MR interval (days)

-

8.1 ± 8.6

-

 DTI-ALPS index (mean ± SD; median [IQR])

0.96 ± 0.09; 0.98 [0.11]

0.80 ± 0.10; 0.78 [0]

 < 0.001

Longitudinal analysis

Acute stage

Remission stage

p

 Age (y)

49.0 ± 11.9

-

 Number of females

34 (81.0%)

-

 Disease onset to MR interval (days)

2.6 ± 1.2

113.9 ± 38.4

-

 DTI-ALPS index (mean ± SD; median [IQR]; n = 42 pairs)

0.78 ± 0.15; 0.77 [0.23]

1.06 ± 0.32; 1.00 [0.38]

 < 0.001

 Distal ICA RI (n = 38 pairs)

0.56 ± 0.06; 0.56 [0.08]

0.54 ± 0.05; 0.54 [0.08]

0.048

Part 2: Vascular investigations^a

Number

r_s

p

 DTI-ALPS index

vs. distal ICA RI

131

- 0.249

0.004

 DTI-ALPS index

vs. mean proximal MCA flow (Disease onset to MR ≥ 50 and < 100 days)

43

0.434

0.004