Table 1 Genes involved in migraine and epilepsy genesis (The table should be placed at the end of the chapter “Genetic mutations linking migraine and epilepsy”)
From: Migraine - a borderland disease to epilepsy: near it but not of it
Gene | Function | Gene locus | Associated Conditions |
|---|---|---|---|
CACNA1A | Regulation of Ca 2+ - channels | 19p13 | FHM 1, episodic ataxia type 2, spinocerebellar ataxia type 2, epilepsy |
ATP1A2 | Regulation of Na+/K+-ATPase | 1q21-q23 | Wide spectrum: i.a. FHM 2, epilepsy, mental retardation, |
SCNA1 | Regulation of Na+ - channels | 2q24 | FHM 3, mesial temporal lobe epilepsy, and hippocampal sclerosis |
PRRT2 | Regulation of Ca2+ - mediated neurotransmitter release and voltage-gated ion channels | 16p11.2 | Wide spectrum: i.a. FHM 4, benign familial infantile epilepsy, and paroxysmal kinesigenic dyskinesia |