Table 2 Tested compounds promoting or counteracting migraine mechanical hypersensitivity and/or allodynia

TRPV1

Capsaicin

Other vanilloids

Acid

Heat

Capsazepine

JNJ-38893777

JNJ-17203212

XPro1595

SB-705498

[50, 54,55,56]

TRPV4

4α-PDD

RN1734

GSK-2193874

[57, 58]

TRPA1

Mustard oil

Umbellulone

Cinnamaldehyde

HC-030031

[58, 59]

TRPM3

Pregnenolone sulfate

CIM0216

progesterone

estrogenes

[59]

TRPM8

Cold

Cooling substances

(e.g. menthol)

AMG2850

RGM8-51

AMTB

[58, 60,61,62]

TRPC4

Lysophosphatidylcholine

ML204

[63]

TRPC5

CFA injections

Paclitaxel

[56, 64]