From: Headaches during pregnancy and the risk of subsequent stroke
G-HA (-) (n = 849,374) | G-HA ( +) (n = 56,813) | P value | |
---|---|---|---|
Prior to pregnancy | |||
Age, y [SD] | 31.73 ± 4.09 | 31.25 ± 4.27 | < 0.001 |
Hypertension, n (%) | 4,495 (0.53) | 574 (1.01) | < 0.001 |
Diabetes, n (%) | 7,606 (0.9) | 792 (1.39) | < 0.001 |
Previous functional disability, n (%)a | 4,681 (0.55) | 597 (1.05) | < 0.001 |
History of headache disorder, n (%) | 28,364 (3.34) | 5,465 (9.62) | < 0.001 |
Migraine | 16,747 (1.97) | 3,592 (6.32) | < 0.001 |
Tension-type headache | 12,092 (1.42) | 2,138 (3.76) | < 0.001 |
Other primary headaches | 1,580 (0.19) | 315 (0.55) | < 0.001 |
During pregnancy | |||
Gestational hypertension, n (%)b | 12,537 (1.48) | 1,279 (2.25) | < 0.001 |
Gestational diabetes, n (%) | 49,699 (5.85) | 3,253 (5.73) | 0.217 |
Clinical outcomes | |||
Any stroke, n (%) | 963 (0.11) | 103 (0.18) | < 0.001 |
Ischemic stroke, n (%) | 488 (0.06) | 49 (0.09) | 0.006 |
Hemorrhagic stroke, n (%) | 509 (0.06) | 56 (0.10) | < 0.001 |
Intracerebral hemorrhage, n (%) | 395 (0.05) | 44 (0.08) | 0.001 |
Subarachnoid hemorrhage, n (%) | 139 (0.02) | 15 (0.03) | 0.076 |