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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex

Fig. 5

Double immunohistochemistry of PR with CGRP, RAMP1 or CLR in TG. A PR and CGRP: PR and CGRP immunoreactive cells in neurons (thick arrows) and their co-localization in the merged image (thick arrow) showed that PR co-localized with CGRP in the cytoplasm of small to medium sized neurons. B PR and RAMP1: RAMP1 was expressed in the cytoplasm of neurons (thick arrow) and in Aδ-fibers (asterisk). PR was expressed in the cytoplasm of neurons (thick arrow), in the neuronal nucleus (thin arrow). In addition, a weak expression was seen in Schwan cells (asterisk). We observed that PR co-localized with RAMP1 in the cytoplasm of medium to large sized neurons (thick arrow in merged image). C PR and CLR: PR co-localized with CLR in the cytoplasm of neurons (thick arrows) and in the satellite glial cells (arrowheads) but not in the fibers. Examples of RAMP1 and CLR immunoreactive fibers are marked with an asterisk

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The Journal of Headache and Pain

ISSN: 1129-2377

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