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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury

Fig. 5

P2X3 immunoreactivity in the TNC in response to astrocyte-specific TNC optogenetic inhibition. Representative immunohistochemistry images showing P2X3 expression in the TNC of (A, C) TN/eNpHR + (B, D) TN/eNpHR- animals in response to astrocyte-specific TNC optogenetic inhibition. Black arrowheads represent the P2X3 expressed areas in the TNC. (E) Quantification of P2X3 immunoreactivity in the TNC of TN rats with optogenetic inhibition with a yellow laser. Data are presented as the mean ± SD. Two-tailed Mann–Whitney test, n = 6/group, **P = 0.0043 compared to another group

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The Journal of Headache and Pain

ISSN: 1129-2377

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