Fig. 3

Multiple intrathecal HNK inhibits LF-PENS-induced depression and cognitive deficits, but not anxiety. a-d Multiple intrathecal 2R, 6R-HNK administration eliminated LF-PENS-induced changes in sucrose preference test (a), tail suspension test (b), forced swimming test (c), new object recognition test (d) at 3-w after stimuli. e Both dosages of 2R, 6R-HNK had no effect on anxiety-like behavior at 2-w after LF-PENS (n = 12 or 14 mice/group), ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 between groups