Table 3 Human provocation studies investigating migraine aura

^aChristiansen et al., 1999 (MA) [21]

GTN

12

6

0

7 to 50

^aSances et al., 2004 (MA) [20]

GTN

22

9

3

NA

^aAfridi et al., 2004 (MA) [19]

GTN

21

14

1

NA

^aHansen et al., 2008 (FHM1) [22]

GTN

8

1

0

< 1 to 10

^aHansen et al., 2010 (FHM) [23]

GTN

23

7

4

NA

^aHansen et al., 2010 (MA) [10]

CGRP

14

8

4

2 to 24

^aHansen et al., 2008 (FHM1 and FMH2) [24]

CGRP

9

2

0

< 1 to 10

^aHansen et al., 2011 (FHM) [25]

CGRP

11

1

0

2 to 15

^cAl-Khazali et al., 2023 (MA/MO)

CGRP

34

24

13

1 to 179

^bButt et al., 2018 (MA/MO) [15]

Cilostazol

16

12

1

2 to 12

^bHougaard et al., 2020 (MA/MO) [17]

Endothelin-1

12

0

0

12 to 48

^bAl-Karagholi et al., 2021 (MA) [18]

Levcromakalim

17

14

10

6 to 50

^bButt et al., 2022 (MA/MO) [16]

Sildenafil

16

9

3

2 to 12