Table 2 Clinical characteristics of aura after calcitonin gene-related peptide provocation
Participant no. | Onset of aura (min) | Duration of aura (min) | Gradually spreading | Localization of aura | Description | Headache onset (min) | Localization of headache | Mimics usual aura | Fulfil aura criteria | Time between aura onset and headache onset | |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Spontaneous | ~ | Visual, 40 Sensory, 45 min | Yes | Right side | Visual: Flickering, foggy | ~ | Right or left side: Parietal, frontal, periorbital. | ~ | Yes | -60 |
CGRP infusion | 360 | Visual, 60 | Yes | Right side | Visual: Flickering, foggy | 40 | Rigth side: Parietal, temporal, Occipital. Left side: Frontal, Parietal, temporal, occipital. | Yes | Yes | 320 | |
2 | Spontaneous | ~ | Visual, 8 Sensory, 5 | Yes | Left side | Visual: Scotoma, flicking, zigzag lines Sensory: numbness | ~ | Left side: Temporal, frontal, periorbital. | ~ | Yes | -180 |
CGRP infusion | 120 | Sensory, 15 min | Yes | Left side fingers and hand | Sensory: Tingling, numbness | 10 | Rigth side: Parietal, temporal, occipital. Left side: Frontal, parietal, temporal, occipital. | Yes | Yes | 110 | |
3 | Spontaneous | ~ | Visual, 30 Sensory, 30 | Visual: No Sensory: Yes | Visual: Left or right side Sensory: Left side | Visual: Scotoma, zigzag lines Sensory: Tingling | ~ | Left side: Frontal, parietal, temporal, occipital, periorbital. | ~ | Yes | -30 |
CGRP infusion | 20 | Visual, 20 Sensory, 40 | Visual: Yes Sensory: Yes | Visual: Left side Sensory: Left side | Visual: Flickering, zigzag lines Sensory: Tingling in fingers, arm, face and tung | 10 | Right side: Frontal, temporal, occipital. Left side: Frontal, parietal, temporal, occipital, periorbital. | Yes | Yes | 10 | |
4 | Spontaneous | ~ | Visual, 60 Sensory, 60 | Yes | Visual: Left or right side Sensory: Left or right side | Visual: Scotoma, black dots Sensory: numbness | ~ | Right side: Frontal, occipital. Left side: Frontal, temporal, occipital. | ~ | Yes | -60 |
CGRP infusion | 10 | Visual, 20 | Yes | Left side | Visual: Flicking, black dots | 10 | Right side: Frontal Left side: Frontal, temporal. | Yes | Yes | 0 | |
5 | Spontaneous | ~ | Visual, 30 Sensory, 720 | Yes | Visual: Left side Sensory: Left side | Visual: Flicking, white dots Sensory: Numbness | ~ | Left or right side: Temporal, occipital. | ~ | Yes | -60 |
CGRP infusion | 30 | Visual, 30 | Yes | Left side | Visual: Central white dots | 10 | Right side: Frontal. Left side: Frontal, temporal. | Yes | Yes | 20 | |
6 | Spontaneous | ~ | Sensory, 30 | Yes | Left side | Sensory: Numbness | ~ | Left side: Periorbital and occipital. | ~ | Yes | -30 |
CGRP infusion | 30 | Sensory, 10 | Yes | Sensory: Left side, face, hand | Sensory: Numbness | 10 | Right side: Frontal, parietal, temporal, Occipital. Lift side: Frontal, parietal, temporal, Occipital. | Yes | Yes | 20 | |
7 | Spontaneous | ~ | Visual, 120 | Yes | Bilateral | Visual: Flicking | ~ | Right side: Frontal Left side: Frontal. | ~ | Yes | -60 |
CGRP infusion | 30 | Visual, 330 | Yes | Bilateral | Visual: Flickering | 10 | Left side: Frontal and temporal. | Yes | Yes | 20 | |
8 | Spontaneous | ~ | Visual, 10 Sensory, 30 | Yes | Visual: Left side Sensory: Left or right side | Visual: Scotoma, flickering Sensory: Numbness in hand, foot, leg | ~ | Left side: Periorbital. | ~ | Yes | -45 |
CGRP infusion | 10 | Visual, 40 Sensory, 15 | Visual: Yes Sensory: No | Visual: Left side Sensory: bilateral, hands | Visual: Flickering Sensory: Tingling, numbness | 20 | Left side: Frontal, occipital. | Yes | Yes | -10 | |
9 | Spontaneous | ~ | Visual, 60 Sensory, 1440 | Yes | Visual: Right side Sensory: Right side | Visual: scotoma, zigzag lines, firework Sensory: Numbness in face, arm, hand | ~ | Right side: Frontal, periorbital, temporal, occipital. | ~ | Yes | -60 |
CGRP infusion | 20 | Visual, 30 Sensory, 520 | Yes | Visual: Right side. Sensory: Right side, face, tongue, arm, hand | Visual: Flickering blue light Sensory: Tingling | 10 | Rigt side: Frontal. | Yes | Yes | 10 | |
10 | Spontaneous | ~ | Visual, 60 Sensory, 150 | Yes | Visual: Bilateral Sensory: Right side face, hand | Visual: Scotoma, zigzag lines, shining light and black dots Sensory: Tingling | ~ | Right side: Periorbital, occipital. | ~ | Yes | -60 |
CGRP infusion | 20 | Visual, 10 min Sensory, 40 min | Yes | Visual: Bilateral Sensory: Right side face, hand | Visual: Shining light and black dots Sensory: Tingling, numbness | 10 | Right side: Periorbital, temporal, occipital. | Yes | Yes | 10 | |
11 | Spontaneous | ~ | Visual, 20 Sensory, 30 | Yes | Visual: Bilateral Sensory: Left side, face, hand, arm, foot, leg | Visual: Flickering light, zigzag lines Sensory: Tingling, numbness | ~ | Right side: Frontal, periorbital, parietal, temporal. | ~ | Yes | -15 |
CGRP infusion | 30 | Sensory, 45 | Yes | Left side, fingers, arm, face | Tingling | 10 | Right side: Frontal, temporal. | Yes | Yes | 20 | |
12 | Spontaneous | ~ | Visual, 60 Sensory, 30 | Yes | Visual: Bilateral Sensory: Right side face, hand, arm | Visual: Scotoma, flickering light, zigzag lines Sensory: Numbness | ~ | Right side: Frontal, periorbital, temporal. Left side: Frontal, periorbital, temporal. | ~ | Yes | -60 |
CGRP infusion | 20 | Visual, 50 | Yes | Bilateral | Flickering | 10 | Right side: Frontal, temporal. Left side: Frontal, temporal. | Yes | Yes | 10 | |
13 | Spontaneous | ~ | Visual, 210 | Yes | Bilateral | Visual: Scotoma, flickering light | ~ | Right side: Frontal, periorbital, temporal. | ~ | Yes | -45 |
CGRP infusion | 30 | Visual, 40 | No | Left side | Flickering | 10 | Right side: Frontal, parital, occipital. | Yes | Yes | 20 |