Fig. 1

 A Headache intensity from 0 min to 12 h in participants who reported migraine aura and migraine headache following calcitonin gene-related peptide infusion, The abscissa refers to the time (min). Median (thick, red line) and individual (thin, black lines) headache intensity on NRS. The median time to onset of migraine aura and migraine headache was 30 min (IQR aura, 20 to 30; IQR headache, 20 to 53). The median time to intake rescue medication was 180 min (IQR, 120 to 300). B Headache intensity from 0 min to 12 h in participants who only reported migraine headache following calcitonin gene-related peptide infusion. The abscissa refers to the time (min). Median (thick, red line) and individual (thin, black lines) headache intensity on NRS. The median time to onset of migraine headache was 40 min (IQR, 20 to 120). The median time to intake rescue medication was 120 min (IQR, 60 to 330). C Headache intensity from 0 min to 12 h in participants who did not report migraine aura or migraine headache following calcitonin gene-related peptide infusion. The abscissa refers to the time (min). Median (thick, red line) and individual (thin, black lines) headache intensity an NRS. The median time to onset of headache was 10 min (IQR, 10 to 20). None of these participants took rescue medication