Table 1 Gepants currently available
From: Mode and site of action of therapies targeting CGRP signaling
| Â | Ubrogepant | Zavegepant | Rimegepant | Atogepant |
|---|---|---|---|---|
Indication | Acute treatment of migraine with or without aura in adults | Acute treatment of migraine with or without aura in adults | Acute treatment of migraine with or without aura in adults Preventive treatment of episodic migraine in adults | Preventive treatment of episodic migraine in adults |
Dosage | 50–100 mg p/o as needed. Second dose 2 h after the initial dose if needed. Max 200 mg/24 h No established safety of treating > 8 migraines / 30 days | 10 mg intranasal No established safety of treating > 8 migraine / 30 days | 75 mg p/o as needed. Max 75 mg /25 h No established safety of using > 18 doses /30 days | 10 mg, 30 mg or 60 mg p/o daily Safe for daily use |