Fig. 2
From: Mode and site of action of therapies targeting CGRP signaling
Crosstalk between CGRP- and Amylin-based therapies. CGRP and amylin 1 (AMY1) receptors are formed by association of either CLR or CTR with RAMP1, respectively. CGRP and amylin are equipotent at the AMY1 receptor, while CGRP is more potent at the canonical CGRP receptor. These receptors have a distinct internalization profile. Current antimigraine drugs targeting CGRP (blue boxes) and potential antimigraine amylin drugs (white boxes) are shown. DACRAs, dual amylin and calcitonin receptor antagonist. Taken and modified from [31, 32]