Skip to main content

Table 2 Sociodemographic and migraine-related clinical characteristics in the OVERCOME (EU) migraine cohort (N = 20,756)

From: Preventive treatment patterns and treatment satisfaction in migraine: results of the OVERCOME (EU) study

Migraine cohort

0–3 HD/m

(n = 13,759)

4–7 HD/m

(n = 4203)

8–14 HD/m

(n = 1730)

 ≥ 15 HD/m

(n = 1064)

Total

(N = 20,756)

Age (years), mean (SD)

40.1 (13.5)

40.7 (13.3)

41.2 (13.5)

42.2 (13.9)

40.4 (13.5)

Sex (female), n (%)

7846 (57.0)

2717 (64.6)

1177 (68.0)

772 (72.6)

12,512 (60.3)

Marital status, n (%)

 Married or living with partner

8972 (65.2)

2831 (67.4)

1144 (66.1)

664 (62.4)

13,611 (65.6)

 Single, separated, divorced or widowed

4697 (34.1)

1340 (31.9)

580 (33.5)

393 (36.9)

7010 (33.8)

 Prefer not to answer

90 (0.7)

32 (0.8)

6 (0.3)

7 (0.7)

135 (0.7)

Employment status, n (%)

 Employed full or part time

9815 (71.3)

3023 (71.9)

1163 (67.2)

619 (58.2)

14,620 (70.4)

 Not employeda

3834 (27.9)

1147 (27.3)

557 (32.2)

429 (40.2)

5967 (28.7)

 Prefer not to answer

110 (0.8)

33 (0.8)

10 (0.6)

16 (1.5)

169 (0.8)

Previously diagnosed with migraine by healthcare provider, n (%)

7269 (52.8)

2805 (66.7)

1169 (67.6)

705 (66.3)

11,948 (57.6)

Age at migraine diagnosis,b mean (SD)

24.0 (10.6)

24.4 (11.0)

25.1 (11.0)

24.3 (11.6)

24.2 (10.8)

HD/m, mean (SD)

1.8 (1.0)

5.4 (1.0)

10.3 (1.7)

20.8 (4.8)

4.2 (4.9)

Number of comorbidities (excluding migraine), n (%)

 1

3667 (26.7)

866 (20.6)

326 (18.8)

156 (14.7)

5015 (24.2)

 2

2716 (19.7)

772 (18.4)

324 (18.7)

145 (13.6)

3957 (19.1)

 3 + 

4305 (31.3)

1868 (44.4)

881 (50.9)

666 (62.6)

7720 (37.2)

MIDAS grade,c n (%)

 I – little or no disability

6689 (48.6)

1043 (24.8)

291 (16.8)

154 (14.5)

8177 (39.4)

 II – mild disability

2988 (21.7)

728 (17.3)

180 (10.4)

80 (7.5)

3976 (19.2)

 III – moderate disability

2438 (17.7)

1036 (24.6)

382 (22.1)

148 (13.9)

4004 (19.3)

 IV – severe disability

1644 (11.9)

1396 (33.2)

877 (50.7)

682 (64.1)

4599 (22.2)

MIBS-4 total score,d n (%)

 0 – no interictal burden

4223 (30.7)

919 (21.9)

345 (19.9)

159 (14.9)

5646 (27.2)

 1–2 – mild interictal burden

2156 (15.7)

642 (15.3)

242 (14.0)

143 (13.4)

3183 (15.3)

 3–4 moderate interictal burden

1714 (12.5)

543 (12.9)

213 (12.3)

147 (13.8)

2617 (12.6)

 5 + – severe interictal burden

5666 (41.2)

2099 (49.9)

930 (53.8)

615 (57.8)

9310 (44.9)

MSQ v2.1 score,e mean (SD)

 Role function – restrictive

67.2 (21.3)

56.6 (19.2)

53.1 (19.6)

47.5 (21.5)

62.9 (21.8)

 Role function – preventive

74.9 (22.9)

67.8 (22.9)

64.8 (23.5)

60.9 (25.5)

71.9 (23.5)

 Role function – emotional function

74.6 (24.1)

65.4 (24.5)

61.2 (25.4)

55.1 (27.3)

70.6 (25.2)

  1. Abbreviations: HD/m Headache days per month, MIBS-4 Migraine Interictal Burden Scale-4, MIDAS Migraine Disability Assessment, MSQ v2.1 Migraine-Specific Quality-of-Life Questionnaire version 2.1, SD Standard deviation
  2. aNot employed includes not employed and looking for work; not employed and not looking for work; long- or short-term disability; student; homemaker; and retired
  3. bAmong those previously diagnosed with migraine by healthcare provider. n = 5710, 2245, 938 and 575 for 0–3, 4–7, 8–14 and ≥ 15 HD/m, respectively, and n = 9468 for total migraine cohort. Note: age at migraine diagnosis was not recorded for all participants who were previously diagnosed with migraine by a healthcare provider
  4. cMIDAS quantifies the number of days a person has missed or had reduced productivity at work, home or social settings over the past three months. Disability grades are then assigned based on the numbers of days, with higher scores indicating more severe disability: grade I = little or no disability (MIDAS score 0–5); grade II = mild (score 6–10); grade III = moderate (score 11–20); and grade IV = severe (score ≥ 21). The MIDAS instrument is considered reliable and valid and is correlated with clinical judgement regarding the need for medical care [5, 24]. Spanish and German versions of the MIDAS instrument are also validated [25, 26]
  5. dMIBS-4 is a four-item instrument that measures the burden related to headache in the time between attacks [20, 21]. The self-administered instrument consists of four items that address disruption at work and school, diminished family and social life, difficulty planning and emotional difficulty. The questionnaire specifically asks about the effect of the disease over the past four weeks on days without a headache attack. Response options include: ‘don’t know/not applicable’, ‘never’, ‘rarely’, ‘some of the time’, ‘much of the time’ or ‘most or all of the time’. Each response has an associated numerical score, with the summation across all four items resulting in a total score ranging from 0 to 12, and the level of interictal burden being categorised into the following: 0 for none, 1–2 mild, 3–4 moderate, and > 5 severe
  6. eMQS v2.1 is a self-administered health status instrument developed to address physical and emotional limitations of specific concern to individuals suffering from migraine headaches [14]. The instrument consists of 14 items that address three domains: (1) role function – restrictive, (2) role function – preventive and (3) role function – emotional function, using a 6-point Likert-type scale of ‘none of the time’, ‘a little bit of the time’, ‘some of the time’, ‘a good bit of the time’, ‘most of the time’ and ‘all of the time’. Raw scores for each dimension are computed as a sum of item responses, with the collective sum providing a total raw score that is then converted to a 0–100 scale, with higher scores indicating a better health-related quality of life (HRQoL), and a positive change in scores reflecting functional improvement [15, 16]
Back to article page

The Journal of Headache and Pain

ISSN: 1129-2377

Contact us