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Table 1 Effect of sex on opto-SD induced periorbital thresholds using multivariable linear regression

From: The effect of sex and estrus cycle stage on optogenetic spreading depression induced migraine-like pain phenotypes

Independent variables

Beta

95% CI

STE

|t|

p

Sex

-18.50

-32.71

-4.29

7.16

2.58

0.011

Opto-SD

-36.53

-50.48

-22.58

7.03

5.20

 < 0.0001

Time of behavior test

-0.67

-2.58

1.22

0.96

0.71

0.481

Single or Repeated stimulation

-15.01

-25.82

-4.19

5.45

2.75

0.007

Opto-SD x Time of behavior test

2.60

0.26

4.93

1.18

2.20

0.030

Sex x Time of behavior test

3.10

0.49

5.71

1.31

2.36

0.020

  1. Periorbital allodynia = β0 + β1(Sex) + β2(Opto-SD) + β3(Time of behavior test) + β4(Single or Repeated stimulation) + β5(Opto-SD x Time of behavior test) + β6(Sex x Time of behavior test)