Fig. 1
From: Notch signaling pathway: a new target for neuropathic pain therapy
Schematic diagram of the canonical Notch signaling pathway. NEC, Notch extra-cellular domain; NTM, membrane-tethered intra-cellular domain; ADAM, A Disintegrin, and Metalloprotease; NICD, Notch intracellular domain; MAML, Mastermind; Co-R, Co-Repressors; CSL, CSL from CBF1 in vertebrates, suppressor of hairless in Drosophila, Lag-1 in Caenorhabditis elegans, RBP-Jκ in mammals