A causal effects of gut microbiota in the development of migraine

Table 1 Positive MR results of causal links between gut microbiome and migraine, migraine with aura and migraine without aura in the IHGC GWAS datasets at the threshold of P < 1e-5 in MR analysis

Outcome	Exposure	Power	F-statistics	Method	No. SNP	*Pval*	OR
Migraine	Class
	Actinobacteria	0.89	25.78	IVW	16	0.0141	1.13(1.03–1.25)
	Family
	ClostridialesvadinBB60group	0.50	22.03		15	0.0445	1.09(1.00–1.18)
	Genus
	Eubacteriumnodatumgroup	0.30	21.58	IVW	11	0.0126	0.92(0.87–0.98)
	Eubacteriumrectalegroup	0.75	21.22	IVW	9	0.0483	0.86(0.75–1.00)
	Ruminococcusgnavusgroup	0.40	21.90		12	0.0402	0.91(0.83–1.00)
	Coprobacter	0.47	21.19	IVW	11	0.0347	1.09(1.01–1.17)
	LachnospiraceaeUCG001	0.96	22.21	IVW	12	0.0006	1.18(1.07–1.30)
	LachnospiraceaeUCG008	0.76	23.11	IVW	11	0.0014	1.14(1.05–1.23)
	Marvinbryantia	0.97	22.02		10	0.0028	1.21(1.07–1.36)
	Roseburia	0.89	20.84	IVW	14	0.0234	1.15(1.02–1.30)
MA	Genus
	Coprococcus3	0.77	21.52	IVW	8	0.0490	1.35(1.00–1.82)
	LachnospiraceaeUCG008	0.44	23.11	IVW	11	0.0317	1.19(1.02–1.40)
	Marvinbryantia	0.99	22.02		10	0.0005	1.48(1.19–1.84)
	RuminococcaceaeNK4A214group	0.88	21.50	IVW	14	0.0051	0.72(0.57–0.91)
	Order
	MollicutesRF9	0.95	20.50	IVW	13	0.0009	1.35(1.13–1.61)
MO	Class
	Actinobacteria	0.93	26.16	IVW	15	0.0142	1.25(1.05–1.50)
	Melainabacteria	0.31	22.05		10	0.0410	0.87(0.76–0.99)
	Family
	BacteroidalesS24.7group	0.36	23.14	IVW	8	0.0491	0.84(0.70–1.00)
	FamilyXI	0.16	22.42	IVW	8	0.0480	0.89(0.80–1.00)
	Genus
	Eubacteriumfissicatenagroup	0.27	21.16	IVW	9	0.0283	1.15(1.02–1.31)
	Eubacteriumnodatumgroup	0.21	21.58	IVW	11	0.0218	0.89(0.80–0.98)
	Anaerotruncus	0.91	20.84	IVW	13	0.0496	1.28(1.00–1.63)
	Catenibacterium	0.21	21.23		5	0.0386	1.17(1.01–1.37)
	Parasutterella	0.54	22.29	IVW	15	0.0333	0.84(0.71–0.99)

MR Mendelian randomization, MA Migraine with aura, MO Migraine without aura, IHGC International headache genetics consortium, GWAS Genome-wide association study, OR Odds ratio, CI Confidential interval

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