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Fig. 7 | The Journal of Headache and Pain

Fig. 7

From: Inhibition of glutamatergic trigeminal nucleus caudalis- vestibular nucleus projection neurons attenuates vestibular dysfunction in the chronic-NTG model of migraine

Fig. 7

Presynaptic mechanism maybe involved in the TNC-VN circuit of chronic-NTG treated rat. A Representative images of the recording CGRP + neurons (neurobiotin-488: green; CGRP: red) by post hoc staining after patch. Scale bar, 20 μm. B Representative traces of the mEPSCs recorded in the CGRP + VN neurons in saline, chronic-NTG, chronic-NTG + AAV-CaMKIIα-hM4D-mCherry + saline, and chronic-NTG + AAV-CaMKIIα-hM4D-mCherry + CNO group. Cumulative fraction of inter-event interval (C) and amplitude (D) of the mEPSCs in the saline (blue line) and chronic-NTG (green line) group. Statistic results of the frequency (E) and amplitude (F) of mEPSCs in the saline (blue box) and chronic-NTG (green box) group. Cumulative fraction of inter-event interval (G) and amplitude (H) of the mEPSCs in the saline (blue line) and chronic-NTG (green line) group. Statistic results of the frequency (I) and amplitude (J) of mEPSCs in the saline (blue box) and chronic-NTG (green box) group (n = 6 neurons from 6 rats). Paired t-test. ***p < 0.001

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The Journal of Headache and Pain

ISSN: 1129-2377

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