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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine

Fig. 6

The graphical Abstract of this study. PACAP/PAC1R may contribute to NTG-induced central sensitization by regulating synaptic plasticity via ERK/CREB/BDNF signaling in CM model. PACAP modulates receptors on neuronal cells and enhances the activation of signaling pathways (ERK) and key transcription factors (CREB), which regulate the synthesis of synapse-associated proteins and adjust synaptic ultrastructure in the TNC. Abbreviations: PACAP, pituitary adenylate cyclase-activating peptide. NTG, nitroglycerin; CM: chronic migraine; TNC, trigeminal nucleus caudalis

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The Journal of Headache and Pain

ISSN: 1129-2377

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