Table 1 Overview of the mentioned lipoprotein papers presenting the set-up, techniques, cohort and main results
Authors | Type of study | Technique | Participants | Main findings |
|---|---|---|---|---|
Onderwater et al. [38] | Cohort | 1H-NMR spectroscopy | Total: 10,153, males and females analyzed separately • 2800 migraine patients • 7353 controls | • ↓ ApoA1 in both males and females • ↓ S-HDL-FC ratio in both males and females • ↓ Omega-3 fatty acids in males |
Harder et al. [39] | Cohort | 1H-NMR spectroscopy | Total: 1825, males and females analyzed concurrently • 313 migraine patients • 512 controls | • Several metabolites found either as predictive for lifetime migraine status (6) or for active migraine status (22) |
Liampas et al. [40] | Meta-analysis | Enzymatic assays or colorimetric method, standard laboratory methods | 12–15 studies with a total ranging from 2538–2889, males and females analyzed concurrently • 1325–1526 migraine patients • 1213–1363 controls | • ↑ TC and TG levels in migraine patients versus controls • Similar HDL-C levels in migraine patients versus controls |
Kurth et al. [41] | Cross-sectional | Immuno- turbidimetric assays and reagent assays | Total: 27,626 exclusively females • 5087 migraine patients • 22,539 controls | • No significantly decreased apoA1 levels in women |
Bellei et al. [42] | Cross-sectional | Two-dimensional gel electrophoresis and mass spectrometry | Total: 45 exclusively females • 30 migraine patients • 15 controls | • ↓ ApoA1 was found in female migraineurs (menstrual and post-menopausal migraine) |
Maghsoumi-Norouzabad et al. [43] | Meta-analysis | Not specified | For duration of migraine: 2 studies with a total of 134 males and females analyzed concurrently • 62 migraine patients • 72 controls | • Duration of migraine decreased with use of omega-3 supplements |