Fig. 2
Results of the meta-analysis performed by Onderwater et al. [38] A. Candidate migraine biomarkers apolipoprotein A1 (apoA1) and the free cholesterol to total lipid ratio in small high-density lipoprotein ratio (S-HDL-FC). Forest plot of the random-effects meta-analyses of the associations with migraine. The effect sizes and 95% confidence intervals (CIs) for apoA1 and S-HDL-FC are shown per cohort. Values from logistic regression with migraine status as dependent variable and metabolite levels, age and sex as independent variables. *p Values after Holm-Bonferroni multiple testing correction (p < 0.0002). I2 = measure of heterogeneity; LUMINA = Leiden University Migraine Neuro-Analysis; NESDA = Netherlands Study of Depression and Anxiety 1&2; NTR = Netherlands Twin Registry; ERF = Erasmus Rucphen Family study; RS = Rotterdam Study. B. Sex-stratified metabolite associations with migraine. Random-effects meta-analysis of 8 cohorts of the metabolite associations with migraine in male (blue squares) and female (purple circles) participants. The effect sizes and 95% confidence intervals (CIs) are presented. The solid squares or circles indicate significance after Holm-Bonferroni multiple testing correction (p < 0.0002)