Fig. 1

ASL perfusion changes for each phase of migraine cycle. A and B CBF maps showing an early left hemisphere hypoperfusion followed by hyperperfusion in areas congruous with aura symptoms (exceeding the boundaries of single vascular territories) (modified from Boulouis et al., 2016 [18]). C Reduced regional CBF in lateral hypothalamus and visual cortex during the preictal phase of migraine attack (modified from Meylakh et al., 2020 [38]). D Increased regional CBF in limbic circuit during the headache phase of migraine (migraine without aura attack) (modified from Stankewitz et al., 2021 [43]). E Increased regional CBF in extrastriate cortex and superior temporal gyrus during the interictal period (migraine with aura) (modified from Michels et al., 2019 [28])