Fig. 5
The effect of NE on HCN2 and the pNR2B/CaMKII/pCREB pathway in CM rats. A Representative western blots of HCN2, pNR2B, CaMKII, pCREB, tNR2B, and tCREB. B-E The expression levels of HCN2, pNR2B, CaMKII, and pCREB were obviously increased in the CM group compared with those in the Sham group, and there was no statistical difference between the CM and the CM + Vehicle groups. The HCN2, pNR2B, CaMKII and pCREB expression levels in the CM + NE group sharply reduced compared to the CM + Vehicle group. (n = 6/group, **p < 0.01, N, S, not significant). F and G There was no substantial difference in tNR2B and tCREB expression levels among the Sham, CM, CM + Vehicle, and CM + NE groups. (n = 6/group, N, S, not significant)