Fig. 11

Regulation of synaptic plasticity by NE or ZD 7288 in the PAG of CM rats. A-E Synaptic ultrastructure in the four groups. A, a: Sham group; B, b: CM group; C, c: CM + Vehicle group; D, d: CM + NE group; E, e: CM + ZD 7288. PSD, postsynaptic density; SC, synaptic cleft; SV, synaptic vesicle. a-e show enlarged versions of the images in A-E. (Scale bars = 200 nm). F and I Representative western blots of PSD95 and Syp. G and H The protein levels of PSD95 and Syp in the CM group were drastically higher than those in the Sham group, and there was no significant difference between the CM group and CM + Vehicle groups. The PSD95 and Syp expression levels in the CM + NE group were seriously reduced compared with those in the CM + Vehicle group. (n = 6/group, **p < 0.01, N, S, not significant). J and K The protein levels of PSD95 and Syp were substantially higher in the CM group than those in the Sham group, and there was no statistical difference between the CM group and CM + Vehicle groups. Compared to the CM + Vehicle group, the levels of PSD95 and Syp were robustly decreased in the CM + ZD 7288 group. (n = 6/group, **p < 0.01, N, S, not significant)