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Table 2 Plasma concentrations of Trp metabolites in healthy controls and interbout period of cluster headache patients

From: Cluster headache and kynurenines

Metab. (nM)

Groups: median ± IQR

p-values between groups

1. Healthy control (n = 22)

2. Cluster interbout (n = 19)

Trp

57,737.78 ± 21,948.78

50,965.09 ± 18,854.21

0.601

KYN

2059.42 ± 720.39

1668.05 ± 526.45

0.010

KYNA

43.56 ± 26.30

39.49 ± 16.14

0.497

ANA

44.18 ± 34.48

35.25 ± 20.56

0.229

3-HK

41.03 ± 15.78

44.31 ± 12.96

0.530

XA

15.41 ± 10.81

13.90 ± 8.92

0.174

3-HANA

49.18 ± 32.17

53.69 ± 31.54

0.320

PICA

48.20 ± 34.74

34.96 ± 24.57

0.296

QUINA

431.58 ± 233.42

453.82 ± 180.95

0.005

5-HT

43.72 ± 311.28

216.34 ± 229.24

0.157

5-HIAA

42.59 ± 21.55

43.89 ± 191.80

0.143

  1. Significant differences were revealed between control and interbout data in cases of KYN and QUINA
  2. IQR interquartile range, Metab metabolites, Trp Tryptophan, KYN L-kynurenine, KYNA Kynurenic acid, ANA Anthranilic acid, 3-HK 3-hydroxikynurenine, XA Xanthurenic acid, 3-HANA 3-hydroxianthranilic acid, PICA Picolinic acid, QUINA Quinolinic acid, 5-HT 5-hydroxytryptamine, 5-HIAA 5-hydroxiindoleaceticacid