Table 1 Demographic and clinical characteristics of responders and non-responders

Patient characteristics

Age

46.77 ± 1.29

47.87 ± 1.48

44.17 ± 2.53

0.189

50.16 ± 1.53

42.72 ± 2.01

0.003

49.06 ± 1.64

45.76 ± 1.7

0.237

Onset age

21.9 ± 1.22

21.99 ± 1.44

21.7 ± 2.3

0.915

23.07 ± 1.74

20.5 ± 1.67

0.295

25.39 ± 2.15

20.36 ± 1.45

0.056

Sex

83, 82%

59, 83%

24, 80%

0.930

47, 85%

36, 78%

0.497

25, 81%

58, 83%

1.000

BMI

21.7 ± 0.39

21.41 ± 0.47

22.38 ± 0.71

0.261

21.83 ± 0.57

21.55 ± 0.53

0.720

22.33 ± 0.86

21.42 ± 0.42

0.283

Migriane characteristics

Chronic Migraine

44, 44%

28, 39%

16, 53%

0.286

20, 36%

24, 52%

0.163

13, 42%

31, 44%

0.998

Aura

26, 26%

16, 23%

10, 33%

0.376

14, 25%

12, 26%

1.000

7, 23%

19, 27%

0.813

Unilateral pain

72, 71%

50, 70%

22, 73%

0.956

38, 69%

34, 74%

0.755

18, 58%

54, 77%

0.086

Pulsating pain

64, 63%

45, 63%

19, 63%

1.000

35, 64%

29, 63%

1.000

17, 55%

47, 67%

0.337

Pain severity

6.07 ± 0.15

6.07 ± 0.18

6.07 ± 0.29

0.991

6.07 ± 0.21

6.07 ± 0.23

0.981

6.1 ± 0.3

6.06 ± 0.18

0.905

Duration

5.12 ± 0.77

3.68 ± 0.47

8.5 ± 2.22

0.004

3.78 ± 0.59

6.71 ± 1.5

0.057

3.87 ± 0.77

5.66 ± 1.04

0.287

Aggravation by routine physical activity

82, 81%

60, 85%

22, 73%

0.301

45, 82%

37, 80%

1.000

28, 90%

54, 77%

0.198

MHD

14.96 ± 0.76

14.00 ± 0.88

17.23 ± 1.45

0.052

13.42 ± 0.99

16.8 ± 1.13

0.027

13.5 ± 1.34

15.6 ± 0.92

0.204

MMD

12.5 ± 0.74

11.63 ± 0.82

14.58 ± 1.53

0.069

11.5 ± 0.95

13.71 ± 1.16

0.138

12.23 ± 1.3

12.63 ± 0.91

0.806

AMD

9.7 ± 0.71

9.67 ± 0.78

9.78 ± 1.56

0.946

9.35 ± 0.85

10.13 ± 1.2

0.590

9.47 ± 1.03

9.81 ± 0.93

0.829

MOH

28, 28%

17, 24%

11, 37%

0.288

12, 22%

16, 35%

0.220

9, 29%

19, 27%

1.000

Associated symptoms

Photophobia—none

22, 22%

10, 14%

12, 40%

0.012

9, 16%

13, 28%

0.186

5, 16%

17, 24%

0.497

- mild

30, 30%

26, 37%

4, 13%

18, 33%

12, 26%

8, 26%

22, 31%

- moderate

32, 32%

24, 34%

8, 27%

21, 38%

11, 24%

13, 42%

19, 27%

- severe

17, 17%

11, 15%

6, 20%

7, 13%

10, 22%

5, 16%

12, 17%

Phonophobia—none

22, 22%

12, 17%

10, 33%

0.337

10, 18%

12, 26%

0.798

7, 23%

15, 21%

0.618

- mild

35, 35%

26, 37%

9, 30%

20, 36%

15, 33%

8, 26%

27, 39%

- moderate

29, 29%

22, 31%

7, 23%

16, 29%

13, 28%

11, 35%

18, 26%

- severe

15, 15%

11, 15%

4, 13%

9, 16%

6, 13%

5, 16%

10, 14%

Nausea/vomitting—none

26, 26%

18, 25%

8, 27%

0.944

15, 27%

11, 24%

0.268

7, 23%

19, 27%

0.062

- mild

41, 41%

28, 39%

13, 43%

18, 33%

23, 50%

8, 26%

33, 47%

- moderate

29, 29%

21, 30%

8, 27%

18, 33%

11, 24%

13, 42%

16, 23%

- severe

5, 5%

4, 6%

1, 3%

4, 7%

1, 2%

3, 10%

2, 3%

Treatment

Triptan response (/3 times)—0

14, 14%

6, 8%

8, 29%

0.082

4, 7%

10, 23%

0.096

2, 6%

12, 18%

0.047

- 1

26, 26%

20, 28%

6, 21%

13, 24%

13, 30%

5, 16%

21, 31%

- 2

26, 26%

20, 28%

6, 21%

17, 31%

9, 20%

13, 42%

13, 19%

- 3

33, 33%

25, 35%

8, 29%

21, 38%

12, 27%

11, 35%

22, 32%

Total prior treatment failures

1.82 ± 0.11

1.66 ± 0.12

2.2 ± 0.23

0.023

1.62 ± 0.14

2.07 ± 0.17

0.040

1.45 ± 0.18

1.99 ± 0.13

0.022

Other scores

GAD-7

4.92 ± 0.39

4.58 ± 0.44

5.73 ± 0.81

0.179

4.82 ± 0.54

5.04 ± 0.57

0.776

5.1 ± 0.7

4.84 ± 0.48

0.767

PHQ-9

5.86 ± 0.42

5.76 ± 0.46

6.1 ± 0.89

0.709

6.07 ± 0.56

5.61 ± 0.64

0.582

6.57 ± 0.7

5.56 ± 0.52

0.271

Medical history

Psychiatric

27, 27%

17, 24%

10, 33%

0.466

14, 25%

13, 28%

0.927

8, 26%

19, 27%

1.000

Gastrointestinal

26, 26%

16, 23%

10, 33%

0.376

14, 25%

12, 26%

1.000

6, 19%

20, 29%

0.465

Vascular

8, 8%

3, 4%

5, 17%

0.087

3, 5%

5, 11%

0.526

2, 6%

6, 9%

1.000

Hormonal

8, 8%

6, 8%

2, 7%

1.000

5, 9%

3, 7%

0.915

3, 10%

5, 7%

0.972

Cancer

11, 11%

7, 10%

4, 13%

0.871

6, 11%

5, 11%

1.000

4, 13%

7, 10%

0.932

Respiratory

11, 11%

9, 13%

2, 7%

0.592

7, 13%

4, 9%

0.744

4, 13%

7, 10%

0.932

Immuno-rheumatologic

7, 7%

4, 6%

3, 10%

0.718

1, 2%

6, 13%

0.069

1, 3%

6, 9%

0.582

Family history of headache

58, 57%

38, 54%

20, 67%

0.317

27, 49%

31, 67%

0.099

13, 42%

45, 64%

0.061