Table 3 Genome wide association studies in migraine from 2010 to 2022

Antilla et al., 2010 [116]

Europeans

2748

17

2142

589

10,747

429,912

1

12^a

1

12^a

Intergenic between MTDH/AEG-1 and PGCP

MTDH/AEG-1 PGCP, SMYD3, INSIG2, TRPM8, MYLK4, ZNF311, NAV2, COG3, SGCZ, AQP9.^a

Ligthart et al., 2011 [123]

Europeans

2446

NA

NA

NA

8534

2,394,913

0

10^a

0

10^a

-

NGFR, AGBL1, MACC1, LIPG, AGA, KIF20B, BMP2, IGLL1, TSPAN2, KDM4C.^a

Chasman et al., 2012        [117]

American women with European ancestry

5122

1826

18,108

2,608,509

0

7^b

0

7^b

-

PRDM16, TRPM8, SEPT7, C8orf79, LRP1.^b

Freilinger et al., 2012        [124]

Europeans

2326

2326

0

0

4580

Approximately 1.4 M

1

12^a

1

12^a

MEF2D

MEF2D, HFM1, RABGAP1L, MARCH4, TGFBR2, RGS12, PHACTR1, FHL5, ADAM28, ASTN2, INA, MMP17.^a

Anttila et al., 2013 [118]

European descent

23,285

7107

95,425

Approximately 2.3 M

12

5

AJAP1, TSPAN2, FHL5, c7orf10, MMP16, PRDM16, MEF2D, TRPM8, TGFBR2, PHACTR1, ASTN2, LRP1.

Gormley et al., 2016        [120]

European descent

59,674

8348

316,078

8,045,569

38

28

LRP1/STAT6/SDR9C7, PRDM16, FHL5/UFL1, TSPAN2/NGF, TRPM8/HJURP, PHACTR1, MEF2D, SLC24A3, FGF6, C7orf10, PLCE1, KCNK5, ASTN2, MRVI1, HPSE2, CFDP1, RNF213, NRP1, SPR149, JAG1, REST/SPINK2, ZCCHC14, HEY2/NCOA7, WSCD1/NLRP1, GJA1, TGFBR2, ITPK1, ADAMTSL4/ECM1, CCM2L/HCK, YAP1, MED14/USP9X, DOCK4/IMMP2L, CARF, ARMS2/HTRA1, IGSF9B, MPPED2, NOTCH4.

Chen et al., 2017 [125]

Asians (Han Chinese)

1005

1005

0

0

1053

642,832

0

4^c

0

4^c

-

DLG2, GFRA1, UPP2, GPR39.^c

Chang et al., 2018 [126]

African-Americans

380

123

2129

522,471

1

1

Near NMUR2 and GLRA1

Choquet et al., 2021 [127]

Multiethnic (East Asian, African American, Hispanic/Latino, European descent)

88,526

NA

NA

NA

841,795

Over 10 M

79

45

JAG1, LEPR, REST, HEY2, NGF, TGFB1, HOXB3, LRP1, PLCE1, HOXB2, HOXB6, YAP1, POLR2A, AMBRA1, TJP2, EP300, LRP4, ARHGAP1, ECM1, HOXB5, HOXB1, MRVI1, ZC3H7B, HTRA1, RPRD2, ZCCHC14, STAT6, MAPKAPK2, C7orf10, KCNK5, C20orf112, ZBTB4, POU4F1, C14orf37, IQCK, C1orf51, LINC00472, BTBD16, MPPED2, YRDC, PRPF3, ARID4A, GPRC5B, THADA, ZNF408, TMEM51, CHRNB1, CHST6, MTF1, MEF2D, INPP5B, CKAP5, RNF213, DGKZ, TSPAN2, CFDP1, KIAA0586, FHL5, ATG13, TIMM9, F2, PSMA3, GPR26, PLEKHA1, TMEM170A, PHB, SLC24A3, L3MBTL2, TARS2, DYRK3, MRPS21, FXN, CHRM4, TMEM91, CHADL, MANEAL, HARBI1, RANGAP1, IER3IP1, UFL1, C1orf122, TRPM8, PHACTR1, ACTR10, NCOA7, C11orf49, PRDM16, SLC45A1-RERE, TMEM51, TSPAN2-NGF, MSL3P1-TRPM8, MIR4791-EFHB, LINC00472-RIMS1, GJA1-HSF2, FXN, ASTN2-LOC100128505, GATA3-SFTA1P, MRGPRE-ZNF195, CALCB, FGF23-FGF6, LRP1-MIR1228, B3GNTL1-METRNL, LINC00310-KCNE2.

Hautakangas et al., 2022     [94]

Europeans

102,084

15,055

771,257

10,843,197

123

86

PRDM16, CAMTA1, TMEM51, INPP5B, MACF1, C1orf87, LEPR, RP4-598G3.1, TGFBR3, TSPAN2, ADAMTSL4, MEF2D, RABGAP1L, PLA2G4A, MAPKAPK2, KIF26B, THADA, ANKRD36C, ZEB2, AC064865.1, RNU6-546P, MYO3B, HOXD10, CARF, TRPM8, TGFBR2, ATRIP, HNRNPA3P8, CADM2, C3orf38, ITGB5, GPR149, SEC63P2, SPINK2, ANKDD1B, SSBP2, ZNF474, SNX24, POU4F3, TIGD6|HMGXB3, NKX2–5, NSD1, PHACTR1, PRL, IER3, EHMT2, KCNK5, KRT19P1, FHL5, REV3L, GJA1, PCMT1, SUGCT, MLXIPL, TSPAN12, PTK2B, RP11-573 J24.1, NFIB, RP11-373A6.1, TJP2, ZNF462, ASTN2, EHMT1, RNA5SP299, MLLT10, PLCE1, HPSE2, CNNM2, RBM20, HTRA1, GPR26, INPP5A, MRGPRE, MRVI1, INSC, MPPED2, AMBRA1, RAB3IL1, RBM14-RBM4|RBM4, YAP1, SPATA19, FGF6, PDZRN4, LRP1, ATP2B1, RP11-690 J15.1, NCOR2, LRCH1, RNF219-AS1, COL4A1, RP11-384 J4.2, LRFN5, ARID4A, DLST, IFT43, ITPK1, SERPINA1, ABHD17C, HMOX2, CFDP1, ZCCHC14, SMG6, ZBTB4, HOXB3, RP11-81 K2.1, MRC2, TBC1D16, RNF213, RBBP8, SKOR2, FECH, CACNA1A, SUGP1, B9D2|TMEM91, JAG1, SLC24A3, C20orf112, ZMYND8, MRPS6, RUNX1, AC006547.14, FAM47A, MED14