Table 3 Lead SNPs of GWAS significant loci in the combined analysis for patients with cluster headache in Taiwan
From: Genome-wide analyses identify novel risk loci for cluster headache in Han Chinese residing in Taiwan
SNP | Chr | Position | Gene | Minor allele | Stage | MAF(Case, Control) | OR | 95% CI | P valuea | eQTL mapped genesc |
|---|---|---|---|---|---|---|---|---|---|---|
rs1556780 | 1 | 223,755,834 | CAPN2 | G | 1 | (0.354, 0.253) | 1.637 | 1.390‒1.927 | 2.34 × 10–9 | CAPN2 |
|  |  |  |  |  | 2 | (0.344, 0.253) | 1.540 | 1.316‒1.801 | 5.31 × 10–8 | |
|  |  |  |  |  | Com | (0.329, 0.253) | 1.586 | 1.416‒1.775 | 7.61 × 10–16 | |
rs10188640 | 2 | 111,983,520 | MERTK | A | 1 | (0.345, 0.257) | 1.522 | 1.297‒1.787 | 2.17 × 10–7 | AC012442.5, FBLN7, MERTK, RGPD8, TMEM87B, TTL, ZC3H8 |
|  |  |  |  |  | 2 | (0.343, 0.260) | 1.481 | 1.266 ‒1.733 | 8.05 × 10–7 | |
|  |  |  |  |  | Com | (0.349, 0.258) | 1.501 | 1.342‒1.679 | 1.25 × 10–12 | |
rs13028839 | 2 | 199,370,629 | SATB2 | A | 1 | (0.096, 0.154) | 0.577 | 0.447–0.746 | 2.02 × 10–5 | C2orf69, SATB2, AC019330.1 |
|  |  |  |  |  | 2 | (0.099, 0.149) | 0.639 | 0.493–0.829 | 3.46 × 10–4 | |
|  |  |  |  |  | Com | (0.102, 0.151) | 0.634 | 0.518‒0.778 | 2.81 × 10–8 |