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Table 2 Efficacy of 240 mg of galcanezumab therapy at week 3 compared to baseline in patients with episodic cluster headache based on the headache diary (n = 33)

From: Real-world experience with 240 mg of galcanezumab for the preventive treatment of cluster headache

 

Baseline

Week 1

Week 2

Week 3

Week 4

Patients with a reduction of at least 50%, n (%)

Patients with a 100% reduction, n (%)

Number of attacks per week

7.0 (6.0, 10.0)

4.0 (1.0, 6.0)

4.0 (0, 6.0)

0 (0, 4.0) b

0.0 (0, 1.0)

26 (78.8)

18 (54.5)

Days with acute medications per weeka

7.0 (3.0, 7.0)

1.5 (0.0, 4.0)

1 (0, 3.0)

0 (0, 1.3) b

0 (0, 0)

23 (79.3)

18 (62.1)

Pain intensity during attacks [0–10]

8.0 (7.0, 9.0)

6.0 (4.8, 7.3)

4.5 (0, 5.3)

0 (0, 5.0) b

0 (0, 1.8)

NA

NA

  1. Data is presented as median (quartile) according to normality of variable
  2. a4 patients did not take any oral abortive medications during baseline
  3. bP-value < 0.001, comparison from baseline to week 3