Table 1 Assessment of inconsistency between direct and indirect comparisons of interventions. Direct, NMA, and indirect values represent effect sizes of mean difference between active and placebo arms in monthly migraine frequency from baseline to end of intervention. NMA = network meta-analysis
Comparison | Number of Studies | NMA | Direct Comparison | Indirect Comparison | Difference between Direct & Indirect Comparison | p-value |
|---|---|---|---|---|---|---|
StrengthTraining:Placebo | 3 | -3.55 | -3.55 | NA | NA | NA |
HighAerobics:Placebo | 3 | -3.13 | -3.21 | -2.62 | -0.60 | 0.85 |
StrengthTraining:Topiramate | 0 | -2.57 | NA | -2.57 | NA | NA |
ModerateAerobics:Placebo | 16 | -2.18 | -2.11 | -7.08 | 4.96 | 0.31 |
HighAerobics:Topiramate | 0 | -2.15 | NA | -2.15 | NA | NA |
ModerateAerobics:Topiramate | 1 | -1.20 | 0.05 | -5.42 | 5.47 | 0.16 |
Topiramate:Placebo | 1 | -0.98 | 0.27 | -5.20 | 5.47 | 0.16 |
HighAerobics:ModerateAerobics | 2 | -0.95 | -0.36 | -1.80 | 1.44 | 0.53 |
HighAerobics:StrengthTraining | 0 | 0.42 | NA | 0.42 | NA | NA |
ModerateAerobics:StrengthTraining | 0 | 1.37 | NA | 1.37 | NA | NA |
Amitriptyline:Placebo | 0 | 3.82 | NA | 3.82 | NA | NA |
Amitriptyline:Topiramate | 0 | 4.80 | NA | 4.80 | NA | NA |
Amitriptyline:ModerateAerobics | 1 | 6 | 6 | NA | NA | NA |
Amitriptyline:HighAerobics | 0 | 6.95 | NA | 6.95 | NA | NA |
Amitriptyline:StrengthTraining | 0 | 7.37 | NA | 7.37 | NA | NA |