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Table 5 Variables predicting ≥ 50% response and ≥ 75% response in patients with chronic migraine (CM): A logistic regression model

From: Predictors of response to anti-CGRP monoclonal antibodies: a 24-week, multicenter, prospective study on 864 migraine patients

Variable

 50% response rate

 75% response rate

Odds ratio

(95% CI)

p-value

Odds ratio

(95% CI)

p-value

Sex

 M

1.00

 

1.00

 

 F

0.93 (0.60–1.35)

0.623

0.86 (0.57–1.30)

0.469

Age (yrs)

1.01 (0.99–1.02)

0.271

1.00 (0.99–1.02)

0.805

BMI

 Normal

1.00

   

 Underweight

1.19 (0.41–3.40)

0.750

  

 Overweight

1.06 (0.56–2.03)

0.849

  

 Obesity

0.21 (0.07–0.64)

0.006

  

UP

 No

1.00

 

1.00

 

 Yes

1.35 (0.95–1.91)

0.093

1.29 (0.92–1.81)

0.133

UAs

 No

1.00

 

1.00

 

 Yes

1.49 (1.05–2.11)

0.026

1.34 (0.95–1.88)

0.099

Allodynia

 No

1.00

 

1.00

 

 Yes

1.14 (0.79–1.64)

0.483

1.23 (0.86–1.74)

0.253

UP + allodynia

 No

1.00

 

1.00

 

 Yes

1.71 (1.04–2.83)

0.034

1.92 (1.22–3.06)

0.005

UP + UAs

 No

1.00

 

1.00

 

 Yes

1.90 (1.15–3.16)

0.012

1.78 (1.14–2.80)

0.012

  1. UP Unilateral pain, UAs Unilateral cranial autonomic symptoms, BMI Body mass index, Underweight < 18.5, Normal weight 18.5 to < 25, Overweight 25 to < 30, Obesity ≥ 30, Hosmer–Lemeshow test for different models ranged from χ2 = 1.233 to χ2 = 8.420, with corresponding p-values ranging from 0.996 to 0.394