Fig.9

Brain activation in chronic migraine models. A-B. The relative c-Fos⁺ neuron density in several brain regions (A, red) and the relative c-Fos⁺ neuron density with OLC treatment (B, green) in the NTG-induced chronic migraine model or LEV-induced chronic migraine model. C. The brain activation and alteration of brain activation with OLC treatment in the NTG-induced chronic migraine model (dark red) and LEV-induced chronic migraine model (pink); No activation (gray); CGRP receptor (green); (Created with BioRender.com). Abbreviations: VEH, vehicle; NTG, nitroglycerin; LEV, levcromakalim; OLC, olcegepant; mPFC, medial prefrontal cortex; ACC, anterior cingulate cortex; PVT, paraventricular thalamic nucleus; vlPAG, ventrolateral periaqueductal gray; Sp5c, caudal part of the spinal trigeminal nucleus