Table 2 Comparable analysis for the association between migraine and the risk of all-cause dementia
Variables | Subjects, No | Dementia cases, No | Person- Years, No | Incidence rate (95% CI) per 10,000 person years | Hazard ratio (95% CI) |
|---|---|---|---|---|---|
Full cohort | |||||
Matched Controls | 44,195 | 3,757 | 348,995 | 107.7 (104.3–111.1) | 1.00 |
Migraine cohort | 44,195 | 4,800 | 343,871 | 139.6 (135.7–143.5) | 1.30 (1.25–1.35) |
Gender | |||||
Men | |||||
Matched Controls | 14,967 | 963 | 110,806 | 86.9 (81.6–92.5) | 1.00 |
Migraine cohort | 14,967 | 1,274 | 108,781 | 117.1 (110.8–123.6) | 1.35 (1.25–1.46) |
Women | |||||
Matched Controls | 29,228 | 2,794 | 238,190 | 117.3 (113.0–121.6) | 1.00 |
Migraine cohort | 29,228 | 3,526 | 235,090 | 150.0 (145.1–154.9) | 1.28 (1.23–1.34) |
Age of migraine diagnosis | |||||
40–59 | |||||
Matched Controls | 18,948 | 303 | 183,685 | 16.5 (14.7–18.4) | 1.00 |
Migraine cohort | 18,948 | 409 | 183,332 | 22.3 (20.3–24.6) | 1.35 (1.17–1.57) |
60– | |||||
Matched Controls | 25,247 | 3,454 | 165,311 | 208.9 (202.2–215.7) | 1.00 |
Migraine cohort | 25,247 | 4,391 | 160,540 | 273.5 (265.7–281.3) | 1.32 (1.26–1.38) |
Migraine aura | |||||
Matched Controls | 44,195 | 3,757 | 348,996 | 107.7 (104.2–111.1) | 1.00 |
Migraine without aura | 16,628 | 1,898 | 136,279 | 139.3 (133.1–145.6) | 1.29 (1.22–1.36) |
Migraine with aura | 4,004 | 456 | 33,883 | 134.6 (122.7–147.5) | 1.24 (1.12–1.36) |
Unspecified | 23,563 | 2,446 | 173,709 | 140.8 (135.3–146.4) | 1.32 (1.26–1.38) |
Time from migraine diagnosis | |||||
0–5 years | |||||
Matched Controls | 44,195 | 1,577 | 187,423 | 84.1 (80.0–88.3) | 1.00 |
Migraine cohort | 44,195 | 2,224 | 185,691 | 119.8 (114.8–124.8) | 1.42 (1.34–1.51) |
6–10 years | |||||
Matched Controls | 30,552 | 1,454 | 116,502 | 124.8 (118.5–131.3) | 1.00 |
Migraine cohort | 30,057 | 1,754 | 114,167 | 153.6 (146.5–160.9) | 1.26 (1.14–1.4) |
10 years or over | |||||
Matched Controls | 15,854 | 726 | 45,070 | 161.1 (149.6–173.1) | 1.00 |
Migraine cohort | 15,532 | 822 | 44,013 | 186.8 (174.3–199.8) | 1.16 (1.05–1.28) |