Table 2 PPPM cost adjusted for migraine-related drug costs over 4 years

Overall

$128.41

$104.37

$102.37

$112.01

-12.8%

 < 0.001

Antidepressants

Prophylaxis

$15.38

$13.67

$12.11

$11.44

-25.6%

 < 0.001

Anticonvulsants

Prophylaxis

$39.91

$45.10

$42.58

$43.82

9.8%

 < 0.001

Beta blockers

Prophylaxis

$22.01

$18.35

$14.65

$13.40

-39.1%

 < 0.001

ACEI/ARB

Prophylaxis

$5.76

$5.55

$5.11

$4.69

-18.5%

 < 0.001

CGRP mABs

Prophylaxis

$109.35

$243.06

$291.17

Triptans

Treatment

$65.96

$49.36

$38.28

$31.92

-51.6%

 < 0.001

Chronic opioids

Treatment

$91.47

$69.81

$64.32

$64.92

-29.0%

 < 0.001

NSAIDs and non-narcotic analgesics

Treatment

$45.34

$37.90

$30.96

$23.90

-47.3%

 < 0.001

Ergotamine

Treatment

$850.56

$788.94

$820.91

$761.99

-10.4%

0.665

Barbiturates

Treatment

$32.85

$29.65

$23.64

$21.83

-33.6%

0.845

Isometheptene

Treatment

$46.60

$35.93

$15.11

Gepants

Treatment

$177.63

Ditans

Treatment

$86.83

Other treatment classes^a

Treatment

$99.72

$98.85

$95.47

$84.37

-15.4%

 < 0.001