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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine

Fig. 5

Blockade of GLUA1 attenuates central sensitization in CM rats. A-C Allodynia in CM rats was ameliorated by NASPM (100 µg). Two-way ANOVA with the Bonferroni post hoc test; n = 6/group; ***P < 0.001 vs. the Sham + DMSO group; ###P < 0.001 vs. the CM + DMSO group. D, E The enhanced GLUA1 trafficking in CM rats was reversed by NASPM as shown by western blot analysis. F, G p-ERK and PSD95 levels were decreased after NASPM administration. One-way ANOVA with Dunnett’s post hoc test; n = 6/group; **P < 0.01, ***P < 0.001 vs. the Sham + DMSO group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. the CM + DMSO group

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The Journal of Headache and Pain

ISSN: 1129-2377

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