Fig. 11

Src family kinases may mediate the regulation of the PI3K signaling pathway by DRD2. A and B The p-SFK level was increased in CM rats and was decreased by quinpirole and further upgraded by sulpiride. p/t-SFK indicates the p-SFK/t-SFK value. One-way ANOVA with Dunnett’s post hoc test; n = 6/group; *P < 0.05, **P < 0.01 vs. the Sham group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. the CM group. C-E PP2(a Src family kinase inhibitor) relieved pain associated with chronic migraine. n = 6/group; Two-way ANOVA with the Bonferroni post hoc test. F, G Western blot analysis revealed that PP2 inhibited PI3K signaling activation and GLUA1 trafficking. One-way ANOVA with Dunnett’s post hoc test; n = 6/group; **P < 0.01, ***P < 0.001 vs. the Sham + DMSO group; #P < 0.05, ###P < 0.001 vs. the CM + DMSO group