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Table 7 Randomized controlled clinical trials in individuals with migraine comparing a monoclonal antibody targeting the CGRP pathway with another migraine preventive agent

From: European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update

Trial

Phase

Monoclonal antiboy/dose

Comparator/dose

Duration

№ of participants

HER-MES [14]

III

Erenumab

70-140 mg (m)

Topiramate

50-100 mg (d)

12 weeks

777

  1. (m) indicates monthly, (d) indicates daily