Fig. 6
The experiments show the rimegepant inhibition of CGRP induced currents in Xenopus Laevis oocytes expressing CGRP-R (A & B) and AMY1-R (C & D). In A-D, the current change to CGRP at each concentration of rimegepant is given in % of the current obtained for CGRP when given alone in 5-7 batches of oocytes. At a given concentration of rimegepant in A & C each point represents the mean of 2-4 identical experiments in one batch of oocytes. In B & D the least square non-lin fit of the c-r relationship of log[rimegepant] vs. response (three parameters) is shown for responses performed on CGRP-R (A) and AMY1-R (C). The 23 data points shown in Fig. A are obtained from experiments performed on 61 oocytes from seven different batches. The same 23 data points are used for the curve fitting in B. The 16 data points shown in C are obtained from experiments performed on 36 oocytes from 5 different batches. The same 16 data points are used for the curve fitting in D