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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model

Fig. 6

Inhibition of PKC activity suppressed NTG-induced overexpression of synaptic associated proteins, reduced downstream phosphorylated ERK and CREB-S133 levels and inhibited neuronal activation after CM. Representative western blot bands and densitometric quantification of PSD-95 (A), Syt-1 (B), Syp (C), PKC (D), p-ERK (E) and p-CREB-133 (F) after CM. n = 6/group. G. Representative micrographs and quantitative analysis of c-Fos staining in VN. The nuclei were stained with DAPI (blue). n = 6/group. Results are mean ± SD. FOV = 1.02 × 106 µm3. One-way ANOVA, Dunnett; *p < 0.05 compared with saline group, #p < 0.05 compared with CM + vehicle group

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The Journal of Headache and Pain

ISSN: 1129-2377

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