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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model

Fig. 4

BIBN4096BS treatment reduced overexpression of synaptic associated proteins and restored the aberrant synaptic ultrastructure in VN after CM. Representative western blot bands and densitometric quantification of PSD-95 (A), Syp (B) and Syt-1 (C) after CM. n = 6/group. D Representative images of the synaptic ultrastructure in VN after CM. Quantitative analysis of PSD thickness (E), length of synaptic activity zone (F), and curvature of synaptic interface (G) after CM. n = 3/group. Representative images (H) and quantitative analysis (I) of the density of dendritic spines in VN after CM. n = 3/group. Results are mean ± SD. One-way ANOVA, Dunnett; *p < 0.05 compared with saline group, #p < 0.05 compared with CM + vehicle group

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The Journal of Headache and Pain

ISSN: 1129-2377

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