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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model

Fig. 3

BIBN4096BS and chelerythrine chloride (CHE) treatment ameliorated mechanical allodynia, thermal hyperalgesia and vestibular dysfunction after CM. A Timeline for the treatment study. BIBN4096BS and CHE (PKC inhibitor) treatment ameliorated the decreased mechanical (B-E) and thermal (F-G) thresholds after CM. BIBN4096BS and CHE treatment alleviated vestibular dysfunction (H-I) after CM. n = 6/group. Results are mean ± SD. Two-way ANOVA, Bonferroni; *p < 0.05 compared with CM + vehicle group, #p < 0.05 compared with before NTG injection

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The Journal of Headache and Pain

ISSN: 1129-2377

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