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Table 3 Montreal Neurological Institute (MNI) coordinates, cluster size and t-score for regions with reduced whole scan and pain-related connectivity changes

From: Alterations in pain processing circuitries in episodic migraine

Brain region MNI coordinate Cluster size t-score
x y z   
Dorsolateral prefrontal cortex whole scan cortical/subcortical connectivity
 putamen      
−26 2 −14 50 5.63
 posterior parietal cortex −34 −14 −6 92 4.64
36 −4 −2 71 4.80
 hippocampus 36 −78 −12 340 5.57
 hypothalamus −62 −54 −4 37 4.59
 orbitofrontal cortex 30 −18 −12 45 4.83
6 −4 −8 27 4.80
 ventral midbrain −40 26 −4 63 4.74
 primary motor cortex −36 36 −16 32 4.55
 dorsolateral prefrontal cortex −6 −24 −10 34 4.35
48 −6 32 21 4.22
−36 14 28 22 4.05
Dorsolateral prefrontal cortex whole scan brainstem connectivity
 rostral ventromedial medulla −1 −40 −51 12 3.54
Dorsolateral prefrontal cortex pain-related changes in brainstem connectivity
 subnucleus reticularis dorsalis/ spinal trigeminal nucleus/rostral ventromedial medulla −3 −44 −54 141 5.86
 spinal trigeminal nucleus 9 −42 −48 35 4.24
 dorsomedial pons 13 −36 −38 101 5.34
 dorsolateral pons 12 −31 − 31 66 4.30
Lateral hypothalamus pain-related changes in brainstem connectivity
 midbrain periaqueductal gray matter −1 −35 −7 45 3.58
 dorsolateral pons 7 −38 − 32 45 4.41
−9 −40 −30 87 3.91
 rostral ventromedial medulla −3 −28 −41 10 4.00