Alterations in pain processing circuitries in episodic migraine

Table 3 Montreal Neurological Institute (MNI) coordinates, cluster size and t-score for regions with reduced whole scan and pain-related connectivity changes

Brain region	MNI coordinate			Cluster size	t-score
Brain region	x	y	z
*Dorsolateral prefrontal cortex whole scan cortical/subcortical connectivity*
putamen
putamen	−26	2	−14	50	5.63
posterior parietal cortex	−34	−14	−6	92	4.64
posterior parietal cortex	36	−4	−2	71	4.80
hippocampus	36	−78	−12	340	5.57
hypothalamus	−62	−54	−4	37	4.59
orbitofrontal cortex	30	−18	−12	45	4.83
orbitofrontal cortex	6	−4	−8	27	4.80
ventral midbrain	−40	26	−4	63	4.74
primary motor cortex	−36	36	−16	32	4.55
dorsolateral prefrontal cortex	−6	−24	−10	34	4.35
	48	−6	32	21	4.22
	−36	14	28	22	4.05
*Dorsolateral prefrontal cortex whole scan brainstem connectivity*
rostral ventromedial medulla	−1	−40	−51	12	3.54
*Dorsolateral prefrontal cortex pain-related changes in brainstem connectivity*
subnucleus reticularis dorsalis/ spinal trigeminal nucleus/rostral ventromedial medulla	−3	−44	−54	141	5.86
spinal trigeminal nucleus	9	−42	−48	35	4.24
dorsomedial pons	13	−36	−38	101	5.34
dorsolateral pons	12	−31	− 31	66	4.30
*Lateral hypothalamus pain-related changes in brainstem connectivity*
midbrain periaqueductal gray matter	−1	−35	−7	45	3.58
dorsolateral pons	7	−38	− 32	45	4.41
dorsolateral pons	−9	−40	−30	87	3.91
rostral ventromedial medulla	−3	−28	−41	10	4.00

ISSN: 1129-2377