Fig. 7

Inhibiting TNC neuroinflammation alleviated hyperalgesia and migraine-like behaviors in NTG-administered rats. (A) The expression of NF-κB p65 and the ratio of NF-κB p-p65/NF-κB p65 in the TNC after ibuprofen treatment. (B and C) The expression of the NF-кB p65 and CGRP mRNAs after lbu treatment. (D) Mechanical threshold recorded in NTG-treated rats after ibuprofen treatment. (E-G) Latency of ear redness, frequency of head scratching and number of cage climbing instances after ibuprofen treatment. Statistical analysis was performed using one-way ANOVA, n = 6, *p < 0.05 compared to the control group; ^#p < 0.05 compared to the NTG group