Enhanced functional connectivity between habenula and salience network in medication-overuse headache complicating chronic migraine positions it within the addiction disorders: an ICA-based resting-state fMRI study

Table 3 Correlation analysis between functional connectivity of habenula-SN and clinical variables of MOH + CM^a subjects

Clinical variables	r	p value	95 % CI of r
Headache history	0.103	0.703	-0.204–0.557
Medication overuse duration	0.512	0.043	0.116–0.790
Attack frequency	0.299	0.260	-0.451–0.702
VAS^b	0.205	0.446	-0.300–0.714
PHQ-9^c	0.482	0.158	-0.333–0.882
GAD-7^d	0.206	0.568	-0.488–0.659

^a MOH + CM medication-overuse headache + chronic migraine; ^b VAS visual analog scale; ^c PHQ-9 Patient Health Questionnaire 9 Depression Scale; ^d GAD-7 Generalized Anxiety Disorder Assessment 7-item Scale

ISSN: 1129-2377