Table 3 Summary of peak coordinates across all contrasts

Across all CH patients

Pre > Post GONB treatment

medial temporal gyrus

left

−70

−20

−14

347

4.72

0.017

0.39

0.39

cerebellum (lobule ix extending to lobule viii)

left

−6

−54

−60

351

4.48

0.016

0.37

0.37

caudate extending to putamen

left

−16

22

−4

430

4.34

0.006

0.36

0.36

Pre < Post GONB treatment

secondary visual cortex (ba18)

right

20

−92

−12

618

4.13

0.001

0.35

0.34

Responders vs Non-responders to GONB at BASELINE

Responders > Non-responders

lateral occipital cortex

right

38

−74

20

333

5.32

0.008

1.29

1.28

Responders < Non-responders

posterior cingulate gyrus extending to primary motor cortex

right

2

−30

48

448

5.18

0.002

1.26

1.24

Responders vs Non-responders to GONB AFTER treatment

Responders > Non-responders

superior lateral occipital cortex

right

38

−74

20

1508

7.24

< 0.001

1.76

1.74

Responders < Non-responders

posterior cingulate cortex

right

−4

−26

18

272

4.41

0.034

1.07

1.06

middle temporal gyrus

left

−68

−46

2

312

5.03

0.019

1.22

1.21

medial prefrontal cortex

left

−12

52

14

115

5.56

0.015*

1.35

1.34

CH patients vs Healthy controls

CH Patients > Health controls

cerebellum (lobule viii)

left

−14

−62

−42

219

4.82

0.025

2.15

2.08

hippocampus

left

−34

−30

−14

756

4.79

< 0.001

2.13

2.06

CH Patients < Health controls

orbitofrontal cortex

right

22

56

−6

1896

7.97

< 0.001

3.55

3.43

rostral anterior insula

right

52

18

2

218

6.77

0.025

3.02

2.92

middle temporal gyrus

right

54

−18

−16

372

6.45

0.002

2.87

2.78