Fig. 3

Intraplantar administration of IL-6 produces no facial responses in female or male rats. Female and male rats had facial hindpaw withdrawal thresholds assessed prior to and following intraplantar injection of 0.1 ng IL-6 (6 females, 6 males) or vehicle (6 females, 6 males). Two-way ANOVA followed by Bonferroni posthoc analysis revealed no significant facial responses in female (A) (F (1, 40) = 1.844, p = 0.1821) or male (B) (no variation among groups) rats