Fig. 2

Intraplantar IL-6 produces hindpaw hypersensitivity in females. Female rats from the cohort also shown in Fig. 3 had baseline hindpaw withdrawal thresholds established prior to receiving intraplantar injection of 0.1 ng IL-6. IL-6 (n = 6) elicited significant effect of treatment on hindpaw hypersensitivity (F (5, 60) = 2.512, p = 0.0394) when compared with animals that received vehicle (n = 6). *p < 0.05, ***p < 0.001