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Table 1 Traits with an inferred causal relationship with migraine

From: Phenome-wide analysis highlights putative causal relationships between self-reported migraine and other complex traits

Trait

GCP

GCP se

GCP pval

rG

rG se

rG pval

Medication: Paracetamol

0.89

0.09

9.70E-23

0.66

0.03

2.75E-90

Coffee consumed

-0.80

0.09

2.40E-20

-0.25

0.10

1.36E-02

Death of a close relative in last 2 years

-0.81

0.14

6.00E-09

0.27

0.06

3.55E-05

Self reported deep venous thrombosis (DVT)

-0.80

0.14

1.59E-08

0.21

0.07

2.61E-03

Benign neoplasm of colon, rectum, anus and anal canal (ICD10)

-0.71

0.13

2.91E-08

0.19

0.05

5.30E-04

Blood clot in the leg diagnosed by a doctor

-0.79

0.15

5.15E-08

0.19

0.07

6.22E-03

Medication: Clopidogrel

-0.76

0.16

1.38E-06

0.27

0.11

1.48E-02

Medication: Dihydrocodeine

-0.77

0.16

1.98E-06

0.47

0.16

3.75E-03

Diaphragmatic hernia (ICD10)

-0.77

0.17

4.85E-06

0.53

0.08

6.45E-11

Stroke diagnosed by doctor

-0.63

0.14

7.55E-06

0.32

0.11

3.83E-03

Medication: Felodipine

-0.73

0.18

3.06E-05

0.27

0.09

2.03E-03

Worked with paints, thinners or glues

-0.72

0.19

1.39E-04

0.28

0.09

1.71E-03

Ever unenthusiastic / disinterested for a whole week

0.71

0.20

4.25E-04

0.34

0.05

8.12E-11

Workplace sometimes had a lot of diesel exhaust

-0.75

0.22

5.55E-04

0.31

0.08

2.44E-04

Ventral hernia (ICD10)

-0.68

0.20

7.04E-04

0.27

0.10

8.35E-03

Self-reported pulmonary embolism

-0.65

0.21

1.45E-03

0.19

0.07

1.13E-02

Current alcohol drinker

0.61

0.19

1.47E-03

-0.39

0.04

1.51E-19

  1. This table shows all traits with a significant (FDR < 5 %) and strong genetic causal proportion (|GCP| > 0.60) with migraine. Due to space constraints, results for all nominally significant genetic correlations for migraine are shown in Supplementary File 1
  2. Trait Trait causally associated with obesity, GCP Genetic causal proportion, GCP se Genetic causal proportion standard deviation, GCP pval Genetic causal proportion unadjusted p-value, rG Genetic correlation, rG se Genetic correlation standard deviation, rG p val Genetic correlation unadjusted p-value